Publications | Anna Nam Lab

Type 1 interferon perturbates clonal competition by reshaping human blood development

Lama C*, Isakov D*, Rosenberg S, Quijada-Álamo M, Saurty-Seerunghen MS, Moein S, Nozais M, Abera TA, Sakaguchi O, Totwani M, Freed G, Zaydon L, Poon CL, Parghi N, Kubas-Meyer A, Xie AX, Omar M, Choi D, Castillo-Tokumori F, Abu-Zeinah G, Dillard A, Ganesan S, Omans ND, Dusaj N, Chamely P, Mimitou E, Smibert P, Kosiorek HE, Dueck AC, Weinberg R, Chaligne R, Marcellino B, Marchionni L, Patel S, Simonson P, Landau DA, Wagenblast E, Hoffman R, Nam AS. (*Equal contribution)

Nature Genetics. 2026 Sept 15.

Human haematopoietic stem cells remember inflammatory stress

Zeng AGX*, Nagree MS*, Jakobsen NA*, Shah S, Varesi A, Kang JRW, Murison A, Cheong JG, Turkalj S, Zhang X, Radtke FA, Abera TA, Lim INX, Jin L, Araújo J, Aguilar-Navarro AG, Parris D, McLeod J, Kim H, Lee HS, Zhang L, Boulanger M, Bader E, Gbeha E, Parkhurst CN, Wagenblast E, Flores-Figueroa E, Wang B, Schwartz GW, Shultz LD, Nam AS, Grimes HL, Josefowicz SZ, Awadalla P, Vyas P, Dick JE, Xie SZ. (*Equal contribution)

Nature. 2026 May 27.

Co-mapping clonal and transcriptional heterogeneity in somatic evolution via GoT-Multi

Pak M*, Saurty-Seerunghen MS*, Wise K, Abera TA, Lama C, Parghi N, Kang T, Sun X, Gao Q, Bao L, Roshal M, Allan JN, Furman RR, Martelotto LG^#, Nam AS^#. (*Equal contribution; ^#Co-corresponding)

Cell Genomics. 2026 Jan 14.

Commentary: Gudera JA, Sankaran VG. Charting clonal evolution and behavior with GoT-Multi. Cell Genomics. 2026 Jan.

Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells

Rodrigues CP, Collins JM, Yang S, Martinez C, Kim JW, Lama C, Nam AS, Alt C, Lin C, Zon LI.

Science. 2024 Sept 13.

CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response

Jutzi JS, Marneth AE, Jiménez-Santos MJ, Hem J, Guerra-Moreno A, Rolles B, Bhatt S, Myers SA, Carr SA, Hong Y, Pozdnyakova O, van Galen P, Al-Shahrour F, Nam AS & Mullally A.

Leukemia. 2022 Dec 06.

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

Nam AS*, Dusaj N*, Izzo F*, Murali R*, Myers RM*, Mouhieddine TH, Sotelo J, Benbarche S, Waarts M, Federico G, Tahri S, Levine R, Abdel-Wahab O, Godley LA, Chaligne R, Ghobrial I^#, Landau DA^#. (*Equal contribution; ^#Co-corresponding)

Nature Genetics. 2022 Sept 22.

Commentary: Voit RA, Sankaran VG. Multi-omics on our multitudes. Nature Genetics. 2022 Sept.

Commentary: Schnabel, J. Study sheds light on precancerous clonal outgrowth in blood cells. Cornell Chronicle. 2022 Sept.

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics

Nam AS, Chaligne R, Landau DA.

Nature Reviews Genetics. 2020 Aug 17.

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Izzo F*, Lee SC*, Poran A, Chaligne R, Gaiti F, Gross B, Murali RR, Deochand SD, Ang C, Jones PW, Nam AS, Kim KT, Kothen-Hill S, Schulman RC, Ki M, Lhoumaud P, Skok JA, Viny AD, Levine RL, Kenigsberg E, Abdel-Wahab O, Landau DA. (*Equal contribution)

Nature Genetics. 2020 Apr;52(4):378-387.

Exploring tumor clonal evolution in bone marrow of patients with diffuse large B-cell lymphoma by deep IGH sequencing and its potential relevance in relapse

Ma J*, Redmond D*, Miyaguchi A, Nam AS, Nie K, Mathew S, Elemento O, Tam W. (*Equal contribution)

Blood Cancer Journal. 2019 Aug 21;9(9):69.

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

Nam AS*, Kim KT*, Chaligne R*, Izzo F, Ang C, Taylor J, Myers RM, Abu-Zeinah G, Brand R, Omans ND, Alonso A, Sheridan C, Mariani M, Dai X, Harrington E, Pastore A, Cubillos-Ruiz JR, Tam W, Hoffman R, Rabadan R, Scandura JM, Abdel-Wahab O, Smibert P, Landau DA. (*Equal contribution)

Nature. 2019 Jul;571(7765):355-360.

Commentary: Raju S, Ye CJ. How mutations express themselves in blood-cell production. Nature. 2019 Jul;571(7765):329-330.

TARGET-seq Takes Aim at Cancer Evolution through Multi-omics Single-Cell Genotyping and Transcriptomics

Chaligne R, Nam AS, Landau DA.

Molecular Cell. 2019 Mar 21;73(6):1092-1094.

Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum

Yin Y^#, Garcia MR, Novak AJ, Saunders AM, Ank RS, Nam AS, Fisher LW^#. (^#Co-corresponding)

PLOS Biology. 2018 Aug 7;16(8):e2005140.

Assessment of the Utility of Cytology and Flow Cytometry of Cerebrospinal Fluid Samples in Clinical Practice

Nam AS, Giorgadze T, Tam W, Chadburn A.

Acta Cytologica. 2018;62(2):130-136.

An intrasinusoidal extracavitary variant of primary effusion lymphoma

Nam AS, Tam W.

Blood. 2017 Aug 10;130(6):836.

Efficient trafficking of acidic proteins out of the endoplasmic reticulum involves a conserved amino terminal IleProVal (IPV)-like tripeptide motif

Nam AS, Yin Y, von Marschall Z, Fisher LW.

Connective Tissue Research. 2014 Aug;55 Suppl 1(0 1):138-41.

Selected Publications