ANNA NAM LAB

Selected Publications

Human haematopoietic stem cells remember inflammatory stress

Human haematopoietic stem cells remember inflammatory stress

Zeng AGX*, Nagree MS*, Jakobsen NA*, Shah S, Varesi A, Kang JRW, Murison A, Cheong JG, Turkalj S, Zhang X, Radtke FA, Abera TA, Lim INX, Jin L, Araújo J, Aguilar-Navarro AG, Parris D, McLeod J, Kim H, Lee HS, Zhang L, Boulanger M, Bader E, Gbeha E, Parkhurst CN, Wagenblast E, Flores-Figueroa E, Wang B, Schwartz GW, Shultz LD, Nam AS, Grimes HL, Josefowicz SZ, Awadalla P, Vyas P#, Dick JE#, Xie SZ#. (*Equal contribution; #Co-supervised)

Nature. 2026 May 27.

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

Nam AS, Dusaj N, Izzo F, Murali R, Myers RM, Mouhieddine TH, Sotelo J, Benbarche S, Waarts M, Federico G, Tahri S, Levine R, Abdel-Wahab O, Godley LA, Chaligne R, Ghobrial I, Landau DA.

Nat Genet. 2022 Sept 22.

Commentary: Voit RA, Sankaran VG. Multi-omics on our multitudes. Nature Genetics. 2022 Sept.

Commentary: Schnabel, J. Study sheds light on precancerous clonal outgrowth in blood cells. Cornell Chronicle. 2022 Sept.

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

Nam AS*, Kim KT*, Chaligne R*, Izzo F, Ang C, Taylor J, Myers RM, Abu-Zeinah G, Brand R, Omans ND, Alonso A, Sheridan C, Mariani M, Dai X, Harrington E, Pastore A, Cubillos-Ruiz JR, Tam W, Hoffman R, Rabadan R, Scandura JM, Abdel-Wahab O, Smibert P#, Landau DA#. (*Equal contribution; #Co-supervised)

Nature. 2019 Jul;571(7765):355-360.

Commentary: Raju S, Ye CJ. How mutations express themselves in blood-cell production. Nature. 2019 Jul;571(7765):329-330.